Urinary marker of oral pregnenolone administration

Details

Serval ID
serval:BIB_66F17D84798A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Urinary marker of oral pregnenolone administration
Journal
Steroids
Author(s)
Saudan  C., Desmarchelier  A., Sottas  P. E., Mangin  P., Saugy  M.
ISSN
0039-128X
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
70
Number
3
Pages
179-183
Abstract
Pregnenolone (PREG) can potentially be abused by athletes to maintain an equilibration of the steroidal environment after sex steroids administrations. Five men volunteers orally ingested 50 mg PREG to determine optimal urinary markers for detection of this steroid. Our findings show that ingestion of PREG has no significant effects on the testosterone/epitestosterone (T/E) and testosterone/luteinizing hormone (T/LH) ratios, whereas variable changes on the carbon isotopic values of three T metabolites: androsterone, etiocholanolone, 50-androstane-3 alpha,17 beta-diol (5 beta-androstanediol) together with 16(5 alpha)-androsten-3 alpha-ol (androstenol) and 5 beta-pregnane-3 alpha,20 alpha-diol (pregnanediol) have been observed. The difference between the carbon isotopic values (delta(13)C-values) of androstenol and pregnanediol is potentially the most reliable marker of exogenous PREG administration in males. For all subjects, the differences differ by 3.0 parts per thousand or more over a period of about 10 h and for both of them the detection window for positivity is extended over 40 h.
Pubmed
Web of science
Create date
08/02/2008 17:44
Last modification date
20/08/2019 14:22
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