Does stenosis severity of native vessels influence bypass graft patency? A prospective fractional flow reserve-guided study

Details

Serval ID
serval:BIB_66B0C1B155C0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Does stenosis severity of native vessels influence bypass graft patency? A prospective fractional flow reserve-guided study
Journal
Annals of Thoracic Surgery
Author(s)
Botman  C. J., Schonberger  J., Koolen  S., Penn  O., Botman  H., Dib  N., Eeckhout  E., Pijls  N.
ISSN
1552-6259 (Electronic)
Publication state
Published
Issued date
06/2007
Volume
83
Number
6
Pages
2093-7
Notes
Journal Article --- Old month value: Jun
Abstract
BACKGROUND: After coronary bypass surgery, occlusion or narrowing of bypass grafts may occur over time. The present study prospectively evaluated the angiographic patency of bypass grafts after 1 year in relation to the preoperative angiographic and functionally severity of the coronary lesion assessed by fractional flow reserve measurement to test the hypothesis that grafting of less critical stenosis may be a risk factor for early dysfunction of the graft. METHODS: The study comprised 164 patients eligible for coronary artery bypass surgery who were not suitable for percutaneous intervention and with at least one intermediate lesion. Fractional flow reserve was measured in all lesions to be grafted to establish if a lesion was functionally significant. The surgeon was blinded to the results of these measurements. One year after surgery, coronary angiography was performed to establish bypass graft patency. RESULTS: At coronary angiography after 1 year, 8.9% of the bypass grafts on functionally significant lesions were occluded, and 21.4% of the bypass grafts on functionally nonsignificant lesions were occluded. There was no difference in angina class or repeat interventions between patients with or without occluded bypass grafts. CONCLUSIONS: The patency of bypass grafts on functionally significant lesions is significantly higher than the patency of bypass grafts on nonsignificant lesions; however, this finding has no clinical relevance because patients with patent or occluded bypass grafts on nonsignificant lesions did not experience an excess of angina or repeat interventions.
Keywords
Adult Aged Aged, 80 and over Blood Pressure Coronary Angiography Coronary Artery Bypass/*adverse effects Coronary Circulation Coronary Stenosis/*surgery Female Graft Occlusion, Vascular/etiology/*radiography Humans Male Middle Aged Prospective Studies Risk Factors
Pubmed
Web of science
Create date
28/01/2008 9:51
Last modification date
20/08/2019 14:22
Usage data