The Microenvironmental Landscape of Brain Tumors.

Details

Serval ID
serval:BIB_66A33B0C2A3A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Microenvironmental Landscape of Brain Tumors.
Journal
Cancer cell
Author(s)
Quail D.F., Joyce J.A.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Publication state
Published
Issued date
13/03/2017
Peer-reviewed
Oui
Volume
31
Number
3
Pages
326-341
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.

Pubmed
Web of science
Create date
21/03/2017 17:51
Last modification date
20/08/2019 14:22
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