Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study.

Details

Serval ID
serval:BIB_667995BB4FC6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study.
Journal
BMC pulmonary medicine
Author(s)
Egelund G.B., Jensen A.V., Andersen S.B., Petersen P.T., Lindhardt B.Ø., von Plessen C., Rohde G., Ravn P.
ISSN
1471-2466 (Electronic)
ISSN-L
1471-2466
Publication state
Published
Issued date
20/04/2017
Peer-reviewed
Oui
Volume
17
Number
1
Pages
66
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Community-acquired pneumonia (CAP) is a severe infection, with high mortality. Antibiotic strategies for CAP differ across Europe. The objective of the study was to describe the epidemiology of CAP in Denmark and evaluate the prognosis of patients empirically treated with penicillin-G/V monotherapy.
Retrospective cohort study including hospitalized patients with x-ray confirmed CAP. We calculated the population-based incidence, reviewed types of empiric antibiotics and duration of antibiotic treatment. We evaluated the association between mortality and treatment with empiric penicillin-G/V using logistic regression analysis.
We included 1320 patients. The incidence of hospitalized CAP was 3.1/1000 inhabitants. Median age was 71 years (IQR; 58-81) and in-hospital mortality was 8%. Median duration of antibiotic treatment was 10 days (IQR; 8-12). In total 45% were treated with penicillin-G/V as empiric monotherapy and they did not have a higher mortality compared to patients treated with broader-spectrum antibiotics (OR 0.92, CI 95% 0.55-1.53).
The duration of treatment exceeded recommendations in European guidelines. Empiric monotherapy with penicillin-G/V was commonly used and not associated with increased mortality in patients with mild to moderate pneumonia. Our results are in agreement with current conservative antibiotic strategy as outlined in the Danish guidelines.
Keywords
Age Distribution, Aged, Aged, 80 and over, Anti-Bacterial Agents/therapeutic use, Community-Acquired Infections/drug therapy, Community-Acquired Infections/mortality, Denmark/epidemiology, Female, Guideline Adherence, Hospital Mortality, Humans, Incidence, Male, Middle Aged, Penicillins/therapeutic use, Pneumonia, Bacterial/drug therapy, Pneumonia, Bacterial/mortality, Prognosis, Retrospective Studies, Time Factors, Community-acquired pneumonia, Penicillin
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2023 13:42
Last modification date
28/04/2023 6:54
Usage data