Morphological assessment of oocyte quality during assisted reproductive technology cycle.

Details

Serval ID
serval:BIB_660F1660B2F8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Morphological assessment of oocyte quality during assisted reproductive technology cycle.
Journal
JBRA assisted reproduction
Author(s)
Sciorio R., Tramontano L., Greco P.F., Greco E.
ISSN
1518-0557 (Electronic)
ISSN-L
1517-5693
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Following the advancement of medically assisted reproduction (MAR) technology, and the rationale to extend the culture to the blastocyst stage, performing elective single embryo transfer (eSET), gamete quality and assessment have acquired large relevance in ART. Embryo quality is strictly correlated with gametes quality and culture conditions. Oocyte maturity assessment is therefore imperative for fertilization and embryo evolution. Mature oocytes at the metaphase II stage result in a higher fertilization rate compared to immature oocytes. Indeed, oocyte morphology evaluation represents an important and challenging task that may serve as a valuable prognostic tool for future embryo development and implantation potential. Different grading systems have been reported to assess human embryos, however, in many cases, it is still a major challenge to select the single embryo to transfer with the highest implantation potential. Further, eSET has conferred a challenge to embryologists, who must try to enhance embryo culture and selection to provide an adequate success rate, whilst reducing the overall number of embryos transferred. Above the standard morphological assessment, there are several invasive or non-invasive approaches for embryo selection such as preimplantation genetic testing, time-lapse technology, proteomics and metabolomics, as well as oxygen utilization and analysis of oxidative stress in culture medium. This short review is not designed to be a comprehensive review of all possible features that may influence oocyte quality. It does give, however, a brief overview and describes the prognostic value of the morphological characteristics of human oocytes on their developmental capacity following ART treatments.
Keywords
healthy offspring, medically assisted reproduction, non-invasive assessment, oocyte biomechanical features, oocyte morphology, oocyte quality, pregnancy outcomes
Pubmed
Open Access
Yes
Create date
14/06/2024 14:03
Last modification date
15/06/2024 7:03
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