How to detect disease progression in pulmonary arterial hypertension.

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State: Public
Version: Final published version
Serval ID
serval:BIB_660CAFB357D4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
How to detect disease progression in pulmonary arterial hypertension.
Journal
European Respiratory Review
Author(s)
Vachiéry J.L., Yerly P., Huez S.
ISSN
1600-0617 (Electronic)
ISSN-L
0905-9180
Publication state
Published
Issued date
2012
Volume
21
Number
123
Pages
40-47
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
Pulmonary arterial hypertension (PAH) is a rapidly progressive disease, ultimately leading to right heart failure and death. Accumulating evidence indicates that intervention early in disease progression results in better outcomes than delaying treatment. In this review we will discuss the assessments and strategies that can be used to monitor disease progression and guide clinical management. Many tools, such as symptoms, functional classification, exercise capacity, haemodynamic measures, findings on cardiac imaging and levels of biomarkers, have shown to be prognostic for survival both at diagnosis and during treatment. However, attempts to define goal thresholds have produced a variety of results. Several groups have developed risk calculators to estimate individual patients' mortality risk, but the accuracy of these tools across different patient populations remains unknown. What is clear is the importance of regularly assessing a range of parameters and then tailoring treatment goals to each patient. In addition, the use of a multidisciplinary team approach is crucial in order to support patients through all aspects of managing their condition. There is still an urgent need for prospective collaborative initiatives to assess novel goals and improve treatment strategies that would allow physicians to personalise and optimise clinical management for their patients with PAH.
Keywords
Disease Management, Disease Progression, Exercise Tolerance/physiology, Hemodynamics/physiology, Humans, Hypertension, Pulmonary/diagnosis, Hypertension, Pulmonary/physiopathology, Prognosis
Pubmed
Open Access
Yes
Create date
09/07/2014 11:11
Last modification date
20/08/2019 14:21
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