Prevalence of risk factors for cardiovascular disease in HIV-infected patients over time: the Swiss HIV Cohort Study

Details

Serval ID
serval:BIB_660672D05879
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence of risk factors for cardiovascular disease in HIV-infected patients over time: the Swiss HIV Cohort Study
Journal
HIV Medicine
Author(s)
Glass  T. R., Ungsedhapand  C., Wolbers  M., Weber  R., Vernazza  P. L., Rickenbach  M., Furrer  H., Bernasconi  E., Cavassini  M., Hirschel  B., Battegay  M., Bucher  H. C.
ISSN
1464-2662 (Print)
Publication state
Published
Issued date
09/2006
Volume
7
Number
6
Pages
404-10
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
OBJECTIVE: Metabolic changes caused by antiretroviral therapy (ART) may increase the risk of coronary heart disease (CHD). We evaluated changes in the prevalence of cardiovascular risk factors (CVRFs) and 10-year risk of CHD in a large cohort of HIV-infected individuals. METHODS: All individuals from the Swiss HIV Cohort Study (SHCS) who completed at least one CVRF questionnaire and for whom laboratory data were available for the period February 2000 to February 2006 were included in the analysis. The presence of a risk factor was determined using cut-offs based on the guidelines of the National Cholesterol Education Program (NCEP ATP III), the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7), the American Diabetes Association, and the Swiss Society for Cardiology. RESULTS: Overall, 8,033 individuals completed at least one CVRF questionnaire. The most common CVRFs in the first completed questionnaire were smoking (57.0%), low high-density lipoprotein (HDL) cholesterol (37.2%), high triglycerides (35.7%), and high blood pressure (26.1%). In total, 2.7 and 13.8% of patients were categorized as being at high (>20%) and moderate (10-20%) 10-year risk for CHD, respectively. Over 6 years the percentage of smokers decreased from 61.4 to 47.6% and the percentage of individuals with total cholesterol >6.2 mmol/L decreased from 21.1 to 12.3%. The prevalence of CVRFs and CHD risk was higher in patients currently on ART than in either pretreated or ART-naive patients. CONCLUSION: During the 6-year observation period, the prevalence of CVRFs remains high in the SHCS. Time trends indicate a decrease in the percentage of smokers and individuals with high cholesterol.
Keywords
Adult *Antiretroviral Therapy, Highly Active Cardiovascular Diseases/*epidemiology/*etiology Cohort Studies Diabetes Mellitus/epidemiology Dyslipidemias/complications/epidemiology HIV Infections/*complications/drug therapy Humans Hypertension/complications/epidemiology Middle Aged Practice Guidelines Prevalence Questionnaires Risk Assessment Risk Factors Switzerland/epidemiology Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 8:52
Last modification date
20/08/2019 14:21
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