[Bone marrow transplantation in congenital defects of immunity]

Details

Serval ID
serval:BIB_65F6FB2D3398
Type
Article: article from journal or magazin.
Collection
Publications
Title
[Bone marrow transplantation in congenital defects of immunity]
Journal
Pediatr Med Chir
Author(s)
Porta F., Notarangelo L. D., Candotti F., Mazzolari E., Lanfranchi A., Ugazio A. G.
ISSN
0391-5387 (Print)
ISSN-L
0391-5387
Publication state
Published
Issued date
1991
Volume
13
Number
1
Pages
27-30
Language
italian
Notes
Porta, F
Notarangelo, L D
Candotti, F
Mazzolari, E
Lanfranchi, A
Ugazio, A G
ita
English Abstract
Italy
Pediatr Med Chir. 1991 Jan-Feb;13(1):27-30.
Abstract
BMT can cure several congenital immunological defects: if in these disease the engrafting is easier, the GVH reactions are more frequent and severe. The possibility to deplete from T lymphocyte the marrow before infusion, has overcame this difficulty. From 1968 183 BMT have been performed in Europe on patients with SCID (70 from HLA-identical donor, 113 from HLA-nonidentical donor). The survival after 2 years is 76% in the first group, and 56% in the second group (100 marrows have been T-depleted with different techniques). Strict isolation procedures before the transplant are very important to achieve good results. The possibility to treat different immunodeficiency With BMT are also discussed.
Keywords
*Bone Marrow Transplantation/immunology/methods, Child, Child, Preschool, Europe, HLA Antigens/immunology, Histocompatibility Testing, Humans, Immunity, Cellular/immunology, Immunologic Deficiency Syndromes/immunology/mortality/*therapy
Pubmed
Create date
01/11/2017 10:29
Last modification date
20/08/2019 14:21
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