Neuropsychological dysfunction in depression: the relationship to regional cerebral blood flow.

Details

Serval ID
serval:BIB_65D97232C0E8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Neuropsychological dysfunction in depression: the relationship to regional cerebral blood flow.
Journal
Psychological Medicine
Author(s)
Dolan R.J., Bench C.J., Brown R.G., Scott L.C., Frackowiak R.S.
ISSN
0033-2917 (Print)
ISSN-L
0033-2917
Publication state
Published
Issued date
1994
Volume
24
Number
4
Pages
849-857
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The relationship between neuropsychological test performance and regional cerebral blood flow (rCBF) was examined in 29 patients meeting Research Diagnostic Criteria (RDC) for major depression. Following a comprehensive neuropsychological assessment two subsets of tests, comprising tests that discriminated between patients and controls or between patients with varying degrees of global cognitive impairment, were selected. These subtests were entered into a principal components analysis (PCA) which generated a two-factor solution, accounting for 50% of the overall variance in test scores. Individual patient loadings on each of these factors were subsequently correlated with regional cerebral blood flow (rCBF), as measured by positron emission tomography (PET). Both factors demonstrated significant correlations with rCBF in the medial prefrontal cortex and frontal polar cortex while for each factor there were also unique patterns of correlations with posterior brain regions. The findings provide additional evidence that neuropsychological deficits in depression are associated with abnormalities in regional brain function and in particular with the function of the medial prefrontal cortex.
Keywords
Adult, Aged, Attention/physiology, Brain Mapping, Cerebral Cortex/blood supply, Cognition Disorders/psychology, Cognition Disorders/radionuclide imaging, Dementia/psychology, Dementia/radionuclide imaging, Depressive Disorder/psychology, Depressive Disorder/radionuclide imaging, Female, Frontal Lobe/blood supply, Humans, Male, Memory, Short-Term/physiology, Mental Recall/physiology, Middle Aged, Neuropsychological Tests, Paired-Associate Learning/physiology, Prefrontal Cortex/blood supply, Regional Blood Flow/physiology, Retention (Psychology)/physiology, Tomography, Emission-Computed
Pubmed
Web of science
Create date
16/09/2011 20:33
Last modification date
20/08/2019 14:21
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