Quantification of the overall contribution of gene-environment interaction for obesity-related traits.

Details

Serval ID
serval:BIB_65CA3DA48279
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quantification of the overall contribution of gene-environment interaction for obesity-related traits.
Journal
Nature communications
Author(s)
Sulc J., Mounier N., Günther F., Winkler T., Wood A.R., Frayling T.M., Heid I.M., Robinson M.R., Kutalik Z.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
13/03/2020
Peer-reviewed
Oui
Volume
11
Number
1
Pages
1385
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The growing sample size of genome-wide association studies has facilitated the discovery of gene-environment interactions (GxE). Here we propose a maximum likelihood method to estimate the contribution of GxE to continuous traits taking into account all interacting environmental variables, without the need to measure any. Extensive simulations demonstrate that our method provides unbiased interaction estimates and excellent coverage. We also offer strategies to distinguish specific GxE from general scale effects. Applying our method to 32 traits in the UK Biobank reveals that while the genetic risk score (GRS) of 376 variants explains 5.2% of body mass index (BMI) variance, GRSxE explains an additional 1.9%. Nevertheless, this interaction holds for any variable with identical correlation to BMI as the GRS, hence may not be GRS-specific. Still, we observe that the global contribution of specific GRSxE to complex traits is substantial for nine obesity-related measures (including leg impedance and trunk fat-free mass).
Keywords
Body Mass Index, Databases, Factual, Gene-Environment Interaction, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Models, Genetic, Obesity/genetics, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, United Kingdom
Pubmed
Open Access
Yes
Create date
02/04/2020 16:30
Last modification date
25/07/2020 5:19
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