Age-related changes in cortico-releasing factor, somatostatin, neuropeptide Y, methionine enkephalin and beta-endorphin in specific rat brain areas

Details

Serval ID
serval:BIB_65B8C364CF26
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Age-related changes in cortico-releasing factor, somatostatin, neuropeptide Y, methionine enkephalin and beta-endorphin in specific rat brain areas
Journal
Brain Research
Author(s)
Kowalski  C., Micheau  J., Corder  R., Gaillard  R., Conte-Devolx  B.
ISSN
0006-8993 (Print)
Publication state
Published
Issued date
06/1992
Volume
582
Number
1
Pages
38-46
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 5
Abstract
We investigated the age-related changes in the tissular protein, cortico-releasing factor (CRF), somatostatin (SOM), neuropeptide Y(NPY), methionine enkephalin (M-ENK) and beta-endorphin (beta-END) levels in frontal cortex, hippocampus, striatum and hypothalamus of young (4-month-old), mature (18-month-old) and senescent (26-month-old) Wistar male rats, bred in a specific pathogen free environment. Between the age of 4 and 18 months, the tissular protein levels increased in all 4 structures studied. The CRF and SOM levels increased in the hippocampus, while the NPY levels decreased. During this time, the NPY content increased in the striatum, whereas the SOM and M-Enk striatal levels decreased. Concomitantly, the NPY and beta-End levels decreased in the hypothalamus. Interestingly, no significant variations were found to occur in the frontal cortex whatever the neuropeptide studied. Between the age of 18 and 26 months, no significant changes in the tissular protein levels were detected, except in the hippocampus. The changes in the neuropeptide concentrations observed during this period depended on the neuropeptide and the brain structure studied. The CRF and beta-End levels decreased in the frontal cortex and the hypothalamus, respectively. The NPY peptidergic systems seem to be preferentially affected by aging processes since 3 out of the 4 structures studied--the frontal cortex, the striatum and the hypothalamus--showed a decrease in their tissular NPY content. During the same period, none of the 5 neuropeptides studied were affected in the hippocampus.
Keywords
Aging/*physiology Analysis of Variance Animals Brain/growth & development/*metabolism Corpus Striatum/metabolism Corticotropin-Releasing Hormone/*metabolism Enkephalin, Methionine/*metabolism Frontal Lobe/metabolism Hippocampus/metabolism Hypothalamus/metabolism Male Neuropeptide Y/*metabolism Organ Specificity Rats Rats, Inbred Strains Somatostatin/*metabolism beta-Endorphin/*metabolism
Pubmed
Web of science
Create date
15/02/2008 16:57
Last modification date
20/08/2019 14:21
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