The failure of physiologic doses of reverse T3 to effect thyroid-pituitary function in man

Details

Serval ID
serval:BIB_65A51057A2DA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The failure of physiologic doses of reverse T3 to effect thyroid-pituitary function in man
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Nicod  P., Burger  A., Strauch  G., Vagenakis  A. G., Braverman  L. E.
ISSN
0021-972X (Print)
Publication state
Published
Issued date
08/1976
Volume
43
Number
2
Pages
478-81
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Abstract
Reverse T3 (3,3',5'-triiodothyronine, rT3), a major product of the peripheral monodeiodination of thyroxine (T4), was administered to normal male volunteers in doses sufficient to sustain an elevated serum rT3 concentration similar to that frequently observed in patients with nonthyroidal illness. No changes in basal serum T4, T3, TSH and prolactin concentrations, nor in the T3, TSH and prolactin responses to iv TRH were observed during rT3 administration. These findings suggest that physiologic increases in serum rT3 concentration probably do not inhibit T4 to T3 conversion or the anterior pituitary TSH and prolactin responses to thyrotropin-releasing hormone (TRH).
Keywords
Adult Humans Male Pituitary Gland/*drug effects Prolactin/blood Thyroid Gland/*drug effects Thyrotropin/blood Thyrotropin-Releasing Hormone/pharmacology Thyroxine/blood Triiodothyronine/blood/*pharmacology
Pubmed
Web of science
Create date
25/01/2008 13:59
Last modification date
20/08/2019 14:21
Usage data