Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_65A415095D9E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments.
Journal
Journal of Clinical Psychopharmacology
Author(s)
Saigi-Morgui N., Vandenberghe F., Delacrétaz A., Quteineh L., Choong E., Gholamrezaee M., Magistretti P., Aubry J.M., von Gunten A., Preisig M., Castelao E., Vollenweider P., Waeber G., Kutalik Z., Conus P., Eap C.B.
ISSN
1533-712X (Electronic)
ISSN-L
0271-0749
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
35
Number
5
Pages
544-552
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Weight gain is a major health problem among psychiatric populations. It implicates several receptors and hormones involved in energy balance and metabolism. Phosphoenolpyruvate carboxykinase 1 is a rate-controlling enzyme involved in gluconeogenesis, glyceroneogenesis and cataplerosis and has been related to obesity and diabetes phenotypes in animals and humans. The aim of this study was to investigate the association of phosphoenolpyruvate carboxykinase 1 polymorphisms with metabolic traits in psychiatric patients treated with psychotropic drugs inducing weight gain and in general population samples. One polymorphism (rs11552145G > A) significantly associated with body mass index in the psychiatric discovery sample (n = 478) was replicated in 2 other psychiatric samples (n1 = 168, n2 = 188), with AA-genotype carriers having lower body mass index as compared to G-allele carriers. Stronger associations were found among women younger than 45 years carrying AA-genotype as compared to G-allele carriers (-2.25 kg/m, n = 151, P = 0.009) and in the discovery sample (-2.20 kg/m, n = 423, P = 0.0004). In the discovery sample for which metabolic parameters were available, AA-genotype showed lower waist circumference (-6.86 cm, P = 0.008) and triglycerides levels (-5.58 mg/100 mL, P < 0.002) when compared to G-allele carriers. Finally, waist-to-hip ratio was associated with rs6070157 (proxy of rs11552145, r = 0.99) in a population-based sample (N = 123,865, P = 0.022). Our results suggest an association of rs11552145G > A polymorphism with metabolic-related traits, especially in psychiatric populations and in women younger than 45 years.
Keywords
Adult, Age Factors, Body Mass Index, Female, Genotype, Humans, Intracellular Signaling Peptides and Proteins/genetics, Longitudinal Studies, Male, Mental Disorders/drug therapy, Middle Aged, Phosphoenolpyruvate Carboxykinase (GTP)/genetics, Polymorphism, Single Nucleotide, Psychotropic Drugs/adverse effects, Psychotropic Drugs/therapeutic use, Sex Factors, Triglycerides/blood, Waist Circumference/genetics, Waist-Height Ratio, Weight Gain/drug effects, Weight Gain/genetics
Pubmed
Web of science
Open Access
Yes
Create date
10/09/2015 9:45
Last modification date
20/08/2019 15:21
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