Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy.

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Ressource 1Download: viruses-10-00351.pdf (288.52 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_6572B8A55D64
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy.
Journal
Viruses
Author(s)
Oechslin F.
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
10
Number
7
Pages
351
Language
english
Abstract
Bacteriophage (phage) therapy, i.e., the use of viruses that infect bacteria as antimicrobial agents, is a promising alternative to conventional antibiotics. Indeed, resistance to antibiotics has become a major public health problem after decades of extensive usage. However, one of the main questions regarding phage therapy is the possible rapid emergence of phage-resistant bacterial variants, which could impede favourable treatment outcomes. Experimental data has shown that phage-resistant variants occurred in up to 80% of studies targeting the intestinal milieu and 50% of studies using sepsis models. Phage-resistant variants have also been observed in human studies, as described in three out of four clinical trials that recorded the emergence of phage resistance. On the other hand, recent animal studies suggest that bacterial mutations that confer phage-resistance may result in fitness costs in the resistant bacterium, which, in turn, could benefit the host. Thus, phage resistance should not be underestimated and efforts should be made to develop methodologies for monitoring and preventing it. Moreover, understanding and taking advantage of the resistance-induced fitness costs in bacterial pathogens is a potentially promising avenue.
Keywords
Animals, Anti-Bacterial Agents/pharmacology, Bacteria/drug effects, Bacteria/virology, Bacterial Vaccines/immunology, Bacteriophages/physiology, Biological Evolution, Drug Resistance, Bacterial, Evolution, Molecular, Humans, Phage Therapy, Virulence Factors, bacteriophage, phage, phage therapy, phage-resistance
Pubmed
Web of science
Open Access
Yes
Create date
17/08/2018 18:43
Last modification date
20/08/2019 14:21
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