Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis

Details

Serval ID
serval:BIB_6561DA523F58
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
Journal
Immunity
Author(s)
Refaeli  Y., Van Parijs  L., London  C. A., Tschopp  J., Abbas  A. K.
ISSN
1074-7613 (Print)
Publication state
Published
Issued date
05/1998
Volume
8
Number
5
Pages
615-23
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: May
Abstract
Activation-induced cell death (AICD) of lymphocytes is an important mechanism of self-tolerance. In CD4+ T cells, AICD is mediated by the Fas pathway and is enhanced by IL-2. To define the mechanisms of this pro-apoptotic action of IL-2, we analyzed CD4+ T cells from wild-type and IL-2-/- mice expressing a transgenic T cell receptor. T cells become sensitive to AICD after activation by antigen and IL-2. IL-2 increases transcription and surface expression of Fas ligand (FasL) and suppresses transcription and expression of FLIP, the inhibitor of apoptosis. The ability of IL-2 to enhance expression of a pro-apoptotic molecule, FasL, and to suppress an inhibitor of Fas signaling, FLIP, likely accounts for the role of this cytokine in potentiating T cell apoptosis.
Keywords
*Adaptor Proteins, Signal Transducing Animals Antigens, CD95/*immunology Antigens, Surface/immunology Apoptosis/*immunology CASP8 and FADD-Like Apoptosis Regulating Protein CD4-Positive T-Lymphocytes/*immunology Carrier Proteins/genetics/immunology Fas Ligand Protein Fas-Associated Death Domain Protein Immune Tolerance Interleukin-2/*physiology *Intracellular Signaling Peptides and Proteins Membrane Glycoproteins/genetics/immunology Mice Trans-Activation (Genetics)
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:18
Last modification date
20/08/2019 14:21
Usage data