Monoclonal Antibodies in Dermatooncology-State of the Art and Future Perspectives.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_6552A87633AA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Monoclonal Antibodies in Dermatooncology-State of the Art and Future Perspectives.
Journal
Cancers
Author(s)
Bobrowicz M., Zagozdzon R., Domagala J., Vasconcelos-Berg R., Guenova E., Winiarska M.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
24/09/2019
Peer-reviewed
Oui
Volume
11
Number
10
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Monoclonal antibodies (mAbs) targeting specific proteins are currently the most popular form of immunotherapy used in the treatment of cancer and other non-malignant diseases. Since the first approval of anti-CD20 mAb rituximab in 1997 for the treatment of B-cell malignancies, the market is continuously booming and the clinically used mAbs have undergone a remarkable evolution. Novel molecular targets are constantly emerging and the development of genetic engineering have facilitated the introduction of modified mAbs with improved safety and increased capabilities to activate the effector mechanisms of the immune system. Next to their remarkable success in hematooncology, mAbs have also an already established role in the treatment of solid malignancies. The recent development of mAbs targeting the immune checkpoints has opened new avenues for the use of this form of immunotherapy, also in the immune-rich milieu of the skin. In this review we aim at presenting a comprehensive view of mAbs' application in the modern treatment of skin cancer. We present the characteristics and efficacy of mAbs currently used in dermatooncology and summarize the recent clinical trials in the field. We discuss the side effects and strategies for their managing.
Keywords
dermatooncology, immune checkpoints, immunotherapy, monoclonal antibodies
Pubmed
Open Access
Yes
Create date
13/10/2019 17:20
Last modification date
05/08/2020 5:26
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