Survey of aspergillosis in non-neutropenic patients in Swiss teaching hospitals.

Details

Serval ID
serval:BIB_653A87FD5022
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Survey of aspergillosis in non-neutropenic patients in Swiss teaching hospitals.
Journal
Clinical Microbiology and Infection
Author(s)
Garbino J., Fluckiger U., Elzi L., Imhof A., Bille J., Zimmerli S.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Publication state
Published
Issued date
2011
Volume
17
Number
9
Pages
1366-1371
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Clin Microbiol Infect 2011; 17: 1366-1371 ABSTRACT: Invasive aspergillosis (IA) is a live-threatening opportunistic infection that is best described in haematological patients with prolonged neutropenia or graft-versus-host disease. Data on IA in non-neutropenic patients are limited. The aim of this study was to establish the incidence, disease manifestations and outcome of IA in non-neutropenic patients diagnosed in five Swiss university hospitals during a 2-year period. Case identification was based on a comprehensive screening of hospital records. All cases of proven and probable IA were retrospectively analysed. Sixty-seven patients were analysed (median age 60 years; 76% male). Sixty-three per cent of cases were invasive pulmonary aspergillosis (IPA), and 17% of these were disseminated aspergillosis. The incidence of IPA was 1.2/10 000 admissions. Six of ten cases of extrapulmonary IA affected the brain. There were six cases of invasive rhinosinusitis, six cases of chronic pulmonary aspergillosis, and cases three of subacute pulmonary aspergillosis. The most frequent underlying condition of IA was corticosteroid treatment (57%), followed by chronic lung disease (48%), and intensive-care unit stays (43%). In 38% of patients with IPA, the diagnosis was established at autopsy. Old age was the only risk factor for post-mortem diagnosis, whereas previous solid organ transplantation and chronic lung disease were associated with lower odds of post-mortem diagnosis. The mortality rate was 57%.
Pubmed
Web of science
Open Access
Yes
Create date
09/09/2011 10:39
Last modification date
20/08/2019 14:21
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