Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors.

Details

Serval ID
serval:BIB_65373E0FF73C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors.
Journal
Blood
Author(s)
Kruithof E.K., Tran-Thang C., Gudinchet A., Hauert J., Nicoloso G., Genton C., Welti H., Bachmann F.
ISSN
0006-4971
Publication state
Published
Issued date
1987
Peer-reviewed
Oui
Volume
69
Number
2
Pages
460-466
Language
english
Abstract
During pregnancy the plasma concentration of two different inhibitors of plasminogen activators (PAIs) increases. The only one found in the plasma of nonpregnant women (PAI1) is immunologically related to a PAI of endothelial cells; its plasma activity, as deduced from the inhibition of single-chain tissue-type plasminogen activator (t-PA), increased from 3.4 +/- 2.3 U/mL (mean +/- 95% confidence limits) in the plasma of nonpregnant women to 29 +/- 7 U/mL at term, and its antigen level, measured by a radioimmunoassay, increased from 54 +/- 17 ng/mL to 144 +/- 25 ng/mL. In pregnancy plasma a second PAI (PAI 2) related to a PAI found in placenta extracts was observed. Its level, quantified with a radioimmunoassay, increased from below the detection limit (approximately 10 ng/mL) in normal plasma to 260 ng/mL at term. One hour after delivery, PAI 1 activities and antigen decreased sharply, but the PAI 2 antigen levels remained constant. Three days later, the PAI 1 antigen levels had fallen to normal levels, but the PAI 2 antigen levels were still at least eightfold above the nonpregnant values. During pregnancy, the t-PA and prourokinase (u-PA) antigen concentrations increased 50% and 200%, respectively, whereas the plasminogen and alpha 2-antiplasmin levels remained constant. Despite the large variations in the levels of PAs and PAIs, the overall fibrinolytic activity as measured in diluted plasma by a radioiodinated fibrin plate assay did not change significantly. Just after delivery, a great increase in the t-PA antigen levels was observed. Three to five days after delivery most parameters of the fibrinolytic system were normal again. Our results demonstrate that during pregnancy and in the puerperium profound alterations of the fibrinolytic system occur that are characterized by increases in PAs and their inhibitors, but these alterations do not affect the overall fibrinolytic activity.
Keywords
Adult, Female, Glycoproteins, Humans, Plasminogen, Plasminogen Activators, Plasminogen Inactivators, Postpartum Period, Pregnancy, Tissue Plasminogen Activator, Urokinase-Type Plasminogen Activator
Pubmed
Web of science
Create date
06/04/2009 13:00
Last modification date
20/08/2019 14:21
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