Isotropic three-dimensional T<sub>2</sub> mapping of knee cartilage: Development and validation.

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Serval ID
serval:BIB_650D527D5900
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Isotropic three-dimensional T<sub>2</sub> mapping of knee cartilage: Development and validation.
Journal
Journal of magnetic resonance imaging
Author(s)
Colotti R., Omoumi P., Bonanno G., Ledoux J.B., van Heeswijk R.B.
ISSN
1522-2586 (Electronic)
ISSN-L
1053-1807
Publication state
Published
Issued date
02/2018
Peer-reviewed
Oui
Volume
47
Number
2
Pages
362-371
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
Publication Status: ppublish
Abstract
1) To implement a higher-resolution isotropic 3D T <sub>2</sub> mapping technique that uses sequential T <sub>2</sub> -prepared segmented gradient-recalled echo (Iso3DGRE) images for knee cartilage evaluation, and 2) to validate it both in vitro and in vivo in healthy volunteers and patients with knee osteoarthritis.
The Iso3DGRE sequence with an isotropic 0.6 mm spatial resolution was developed on a clinical 3T MR scanner. Numerical simulations were performed to optimize the pulse sequence parameters. A phantom study was performed to validate the T <sub>2</sub> estimation accuracy. The repeatability of the sequence was assessed in healthy volunteers (n = 7). T <sub>2</sub> values were compared with those from a clinical standard 2D multislice multiecho (MSME) T <sub>2</sub> mapping sequence in knees of healthy volunteers (n = 13) and in patients with knee osteoarthritis (OA, n = 5).
The numerical simulations resulted in 100 excitations per segment and an optimal radiofrequency (RF) excitation angle of 15°. The phantom study demonstrated a good correlation of the technique with the reference standard (slope 0.9 ± 0.05, intercept 0.2 ± 1.7 msec, R <sup>2</sup> ≥ 0.99). Repeated measurements of cartilage T <sub>2</sub> values in healthy volunteers showed a coefficient of variation of 5.6%. Both Iso3DGRE and MSME techniques found significantly higher cartilage T <sub>2</sub> values (P < 0.03) in OA patients. Iso3DGRE precision was equal to that of the MSME T <sub>2</sub> mapping in healthy volunteers, and significantly higher in OA (P = 0.01).
This study successfully demonstrated that high-resolution isotropic 3D T <sub>2</sub> mapping for knee cartilage characterization is feasible, accurate, repeatable, and precise. The technique allows for multiplanar reformatting and thus T <sub>2</sub> quantification in any plane of interest.
1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:362-371.
Keywords
Adult, Aged, Cartilage, Articular/diagnostic imaging, Cartilage, Articular/pathology, Cross-Sectional Studies, Feasibility Studies, Female, Humans, Image Interpretation, Computer-Assisted/methods, Imaging, Three-Dimensional/methods, Knee Joint/diagnostic imaging, Knee Joint/pathology, Magnetic Resonance Imaging/methods, Male, Middle Aged, Osteoarthritis, Knee/diagnostic imaging, Osteoarthritis, Knee/pathology, Phantoms, Imaging, Reproducibility of Results, Sensitivity and Specificity, 3T, T2 mapping, isotropic 3D, knee cartilage, osteoarthritis
Pubmed
Web of science
Open Access
Yes
Create date
16/05/2017 17:19
Last modification date
20/08/2019 15:21
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