Suprasellar germinomas in childhood and adolescence: diagnostic pitfalls

Details

Serval ID
serval:BIB_64C60E3FFD86
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Suprasellar germinomas in childhood and adolescence: diagnostic pitfalls
Journal
Journal of Pediatric Endocrinology and Metabolism
Author(s)
Ramelli  G. P., von der Weid  N., Stanga  Z., Mullis  P. E., Buergi  U.
ISSN
0334-018X (Print)
Publication state
Published
Issued date
12/1998
Volume
11
Number
6
Pages
693-7
Notes
Journal Article --- Old month value: Nov-Dec
Abstract
The clinical and neuro-endocrine data of seven young male patients with suprasellar germinomas seen between 1984 and 1992 are reported. The most common initial symptom was 'idiopathic' central diabetes insipidus (DI), which occurred in all seven patients. The time interval between the appearance of this first clinical sign and the definitive diagnosis of a suprasellar germinoma ranged from 3 to 66 months. Raised prolactin levels and growth hormone deficiency were indicators of a process located in the hypothalamic-pituitary region. An increased beta-HCG level in the serum or the CSF confirmed the diagnostic suspicion of a germinoma and was helpful as a tumor marker in follow-up. Neuro-radiologic studies (CT or MRI) were also disappointing in the early stage when patients presented only with DI. Later on, as patients developed additional symptoms or signs related to the tumor, imaging studies were positive. Given the variable rate of tumor progression, the nonspecific early signs of hypothalamic-pituitary dysfunction (DI) as well as the often negative early imaging studies, the diagnosis of suprasellar germinoma is difficult but should always be considered in the presence of so-called 'idiopathic' central DI. Repeated brain MRIs are mandatory in young patients with idiopathic DI in order not to miss an underlying suprasellar germinoma.
Keywords
Adolescent Adult Brain Neoplasms/complications/*diagnosis/physiopathology Child Chorionic Gonadotropin, beta Subunit, Human/blood/cerebrospinal fluid Diabetes Insipidus/diagnosis/etiology Diagnosis, Differential Germinoma/complications/*diagnosis/physiopathology Humans Magnetic Resonance Imaging Male Prolactin/blood *Sella Turcica Tomography, X-Ray Computed
Pubmed
Web of science
Create date
25/01/2008 10:35
Last modification date
20/08/2019 14:21
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