Postmortem diagnosis of drug-induced anaphylactic death.

Details

Serval ID
serval:BIB_64A0D842F5E5
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Postmortem diagnosis of drug-induced anaphylactic death.
Journal
Journal of forensic and legal medicine
Author(s)
Palmiere C.
ISSN
1878-7487 (Electronic)
ISSN-L
1752-928X
Publication state
Published
Issued date
07/2016
Peer-reviewed
Oui
Volume
41
Pages
28-29
Language
english
Notes
Publication types: Letter ; Comment
Publication Status: ppublish
Abstract
Kounis syndrome is defined as the concurrence of acute coronary syndromes including coronary spasm, acute myocardial infarction, and stent thrombosis, together with conditions associated with mast cell and platelet activation, involving interrelated and interacting inflammatory cells. Mast cells influence the inflammatory process decisively, though they are numerically inferior in this inflammatory cascade. Accumulation of eosinophils and mast cells in the splenic red pulp is frequently observed in anaphylactic deaths and can be considered a reliable finding for the postmortem diagnosis of this condition. Moreover, a high concentration of mast cell tryptase in serum and increased numbers of eosinophils and mast cells in the spleen make the diagnosis of anaphylactic death almost conclusive. Increased mast cell tryptase levels in postmortem serum, individually considered, do not allow the diagnosis of anaphylaxis-related death to be reached. On the other hand, neither does identification of mast cells and eosinophils within the coronary artery wall and the myocardium, individually considered, allow the hypothesis of anaphylaxis-related death to be formulated.

Keywords
Anaphylaxis/blood, Autopsy, Eosinophils/metabolism, Humans, Mast Cells/metabolism, Tryptases/blood
Pubmed
Web of science
Create date
03/05/2016 12:47
Last modification date
20/08/2019 14:20
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