Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor.

Details

Serval ID
serval:BIB_649506F5A988
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor.
Journal
Journal of Neuroscience
Author(s)
Thiele T.E., Koh M.T., Pedrazzini T.
ISSN
1529-2401[electronic]
Publication state
Published
Issued date
2002
Volume
22
Number
3
Pages
208
Language
english
Abstract
We have shown previously that voluntary ethanol consumption and resistance to ethanol-induced sedation are inversely related to neuropeptide Y (NPY) levels in NPY-knock-out (NPY(-/-)) and NPY-overexpressing mice. In the present report, we studied knock-out mice completely lacking the NPY Y1 receptor (Y1(-/-)) to further characterize the role of the NPY system in ethanol consumption and neurobiological responses to this drug. Here we report that male Y1(-/-) mice showed increased consumption of solutions containing 3, 6, and 10% (v/v) ethanol when compared with wild-type (Y1(+/+)) control mice. Female Y1(-/-) mice showed increased consumption of a 10% ethanol solution. In contrast, Y1(-/-) mice showed normal consumption of solutions containing either sucrose or quinine. Relative to Y1(+/+) mice, male Y1(-/-) mice were found to be less sensitive to the sedative effects of 3.5 and 4.0 gm/kg ethanol as measured by more rapid recovery from ethanol-induced sleep, although plasma ethanol levels did not differ significantly between the genotypes. Finally, male Y1(-/-) mice showed normal ethanol-induced ataxia on the rotarod test after administration of a 2.5 gm/kg dose. These data suggest that the NPY Y1 receptor regulates voluntary ethanol consumption and some of the intoxicating effects caused by administration of ethanol.
Keywords
Alcohol Drinking, Alcoholic Intoxication, Animals, Behavior, Animal, Drug Resistance, Ethanol, Female, Male, Mice, Mice, Knockout, Motor Activity, Phenotype, Quinine, Receptors, Neuropeptide Y, Sex Factors, Sucrose
Pubmed
Web of science
Create date
25/01/2008 8:45
Last modification date
20/08/2019 14:20
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