Fluorescence guidance in skull base surgery: Applications and limitations - A systematic review.

Details

Serval ID
serval:BIB_64709CCA91C7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fluorescence guidance in skull base surgery: Applications and limitations - A systematic review.
Journal
Brain & spine
Author(s)
Suero Molina E., Bruneau M., Reuter G., Shahein M., Cavallo L.M., Daniel R.T., Kasper E.M., Froelich S., Jouanneau E., Manet R., Messerer M., Mazzatenta D., Meling T.R., Roche P.H., Schroeder H.W., Tatagiba M., Visocchi M., Prevedello D.M., Stummer W., Cornelius J.F.
Working group(s)
EANS Skull Base Section
ISSN
2772-5294 (Electronic)
ISSN-L
2772-5294
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Volume
4
Pages
103328
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Intraoperative fluorescence guidance is a well-established surgical adjunct in high-grade glioma surgery. In contrast, the clinical use of such dyes and technology has been scarcely reported in skull base surgery.
We aimed to systematically review the clinical applications of different fluorophores in both open and endonasal skull base surgery.
We performed a systematic review and discussed the current literature on fluorescence guidance in skull base surgery.
After a comprehensive literature search, 77 articles on skull base fluorescence guidance were evaluated. A qualitative analysis of the articles is presented, discussing clinical indications and current controversies. The use of intrathecal fluorescein was the most frequently reported in the literature. Beyond that, 5-ALA and ICG were two other fluorescent dyes most extensively discussed, with some experimental fluorophore applications in skull base surgery.
Intraoperative fluorescence imaging can serve as an adjunct technology in skull base surgery. The scope of initial indications of these fluorophores has expanded beyond malignant glioma resection alone. We discuss current use and controversies and present an extensive overview of additional indications for fluorescence imaging in skull base pathologies. Further quantitative studies will be needed in the future, focusing on tissue selectivity and time-dependency of the different fluorophores currently commercially available, as well as the development of new compounds to expand applications and facilitate skull base surgeries.
Keywords
5-ALA, Endoscopic endonasal surgery, Fluorescein, Fluorescence-guided resection, Indocyanine-green, Skull base tumors
Pubmed
Open Access
Yes
Create date
27/09/2024 16:11
Last modification date
28/09/2024 7:09
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