Long-Term Recovery After Endothelial Colony-Forming Cells or Human Umbilical Cord Blood Cells Administration in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy.

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Version: Final published version
Serval ID
serval:BIB_6459AEA2067C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-Term Recovery After Endothelial Colony-Forming Cells or Human Umbilical Cord Blood Cells Administration in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy.
Journal
Stem cells translational medicine
Author(s)
Grandvuillemin I., Garrigue P., Ramdani A., Boubred F., Simeoni U., Dignat-George F., Sabatier F., Guillet B.
ISSN
2157-6564 (Print)
ISSN-L
2157-6564
Publication state
Published
Issued date
11/2017
Peer-reviewed
Oui
Volume
6
Number
11
Pages
1987-1996
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
Neonatal hypoxic-ischemic encephalopathy (NHIE) is a dramatic perinatal complication, associated with poor neurological prognosis despite neuroprotection by therapeutic hypothermia, in the absence of an available curative therapy. We evaluated and compared ready-to-use human umbilical cord blood cells (HUCBC) and bankable but allogeneic endothelial progenitors (ECFC) as cell therapy candidate for NHIE. We compared benefits of HUCBC and ECFC transplantation 48 hours after injury in male rat NHIE model, based on the Rice-Vannucci approach. Based on behavioral tests, immune-histological assessment and metabolic imaging of brain perfusion using single photon emission computed tomography (SPECT), HUCBC, or ECFC administration provided equally early and sustained functional benefits, up to 8 weeks after injury. These results were associated with total normalization of injured hemisphere cerebral blood flow assessed by SPECT/CT imaging. In conclusion, even if ECFC represent an efficient candidate, HUCBC autologous criteria and easier availability make them the ideal candidate for hypoxic-ischemic cell therapy. Stem Cells Translational Medicine 2017;6:1987-1996.
Keywords
Animals, Brain/blood supply, Brain/diagnostic imaging, Brain/physiopathology, Cells, Cultured, Cerebrovascular Circulation, Endothelial Progenitor Cells/cytology, Humans, Hypoxia-Ischemia, Brain/therapy, Male, Mesenchymal Stem Cell Transplantation/methods, Rats, Rats, Sprague-Dawley, Umbilical Cord/cytology, Endothelial colony-forming cells, Human umbilical cord blood cells, Neonatal hypoxic ischemic encephalopathy, Rat model, Single photon emission computed tomography
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2017 8:31
Last modification date
20/08/2019 15:20
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