Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells
Details
Serval ID
serval:BIB_6432A0F57BD7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells
Journal
Blood
ISSN
0006-4971 (Print)
Publication state
Published
Issued date
03/2007
Volume
109
Number
5
Pages
2058-65
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 1
Research Support, Non-U.S. Gov't --- Old month value: Mar 1
Abstract
The naturally occurring population of dedicated regulatory T cells that coexpress CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of beta-galactoside-binding proteins, galectin-1, is overexpressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibitory effects of human and mouse CD4+CD25+ T cells. Reduced regulatory activity was observed in CD4+CD25+ T cells obtained from galectin-1-homozygous null mutant mice. These results suggest that galectin-1 is a key effector of the regulation mediated by these cells.
Keywords
Animals
Antibodies, Monoclonal/immunology
Biological Markers
CD4-Positive T-Lymphocytes/*immunology/*metabolism
Cell Nucleus/metabolism
Cell Separation
Cells, Cultured
Culture Media
Cytoplasm/metabolism
Galectin 1/immunology/*metabolism
Humans
Immunoprecipitation
Interleukin-2 Receptor alpha Subunit/*metabolism
Lymphocyte Activation/immunology
Mice
Receptors, Antigen, T-Cell/immunology
T-Lymphocytes, Regulatory/immunology
Pubmed
Web of science
Create date
25/01/2008 13:45
Last modification date
20/08/2019 14:20