The relationship between bone strain index, bone mass, microarchitecture and mechanical behavior in human vertebrae: an ex vivo study.

Details

Serval ID
serval:BIB_642FEA8CA2EC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The relationship between bone strain index, bone mass, microarchitecture and mechanical behavior in human vertebrae: an ex vivo study.
Journal
Osteoporosis international
Author(s)
Roux J.P., Duboeuf F., Sornay-Rendu E., Rinaudo L., Ulivieri F.M., Wegrzyn J., Chapurlat R.
ISSN
1433-2965 (Electronic)
ISSN-L
0937-941X
Publication state
Published
Issued date
06/2024
Peer-reviewed
Oui
Volume
35
Number
6
Pages
1069-1075
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The aim of this study was to determine whether the Bone Strain Index (BSI), a recent DXA-based bone index, is related to bone mechanical behavior, microarchitecture and finally, to determine whether BSI improves the prediction of bone strength and the predictive role of BMD in clinical practice.
Bone Strain Index (BSI) is a new DXA-based bone index that represents the finite element analysis of the bone deformation under load. The current study aimed to assess whether the BSI is associated with 3D microarchitecture and the mechanical behavior of human lumbar vertebrae.
Lumbar vertebrae (L3) were harvested fresh from 31 human donors. The anteroposterior BMC (g) and aBMD (g/cm2) of the vertebral body were measured using DXA, and then the BSI was automatically derived. The trabecular bone volume (Tb.BV/TV), trabecular thickness (Tb.Th), degree of anisotropy (DA), and structure model index (SMI) were measured using µCT with a 35-µm isotropic voxel size. Quasi-static uniaxial compressive testing was performed on L3 vertebral bodies under displacement control to assess failure load and stiffness.
The BSI was significantly correlated with failure load and stiffness (r = -0.60 and -0.59; p < 0.0001), aBMD and BMC (r = -0.93 and -0.86; p < 0.0001); Tb.BV/TV and SMI (r = -0.58 and 0.51; p = 0.001 and 0.004 respectively). After adjustment for aBMD, the association between BSI and stiffness, BSI and SMI remained significant (r = -0.51; p = 0.004 and r = -0.39; p = 0.03 respectively, partial correlations) and the relation between BSI and failure load was close to significance (r = -0.35; p = 0.06).
The BSI was significantly correlated with the microarchitecture and mechanical behavior of L3 vertebrae, and these associations remained statistically significant regardless of aBMD.
Keywords
Humans, Lumbar Vertebrae/physiology, Lumbar Vertebrae/diagnostic imaging, Lumbar Vertebrae/physiopathology, Female, Bone Density/physiology, Aged, Male, Middle Aged, Stress, Mechanical, Finite Element Analysis, Absorptiometry, Photon/methods, Biomechanical Phenomena/physiology, X-Ray Microtomography/methods, Cancellous Bone/diagnostic imaging, Cancellous Bone/physiology, Weight-Bearing/physiology, Aged, 80 and over, Compressive Strength/physiology, Adult, Anisotropy, BMD, Bone microarchitecture, Bone strain index, Bone strength, Fracture prediction, Osteoporosis
Pubmed
Web of science
Create date
25/03/2024 15:48
Last modification date
14/06/2024 7:03
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