Effects of Brain Size on Adult Neurogenesis in Shrews.

Details

Serval ID
serval:BIB_641FC3A95C0A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of Brain Size on Adult Neurogenesis in Shrews.
Journal
International journal of molecular sciences
Author(s)
Bartkowska K., Turlejski K., Tepper B., Rychlik L., Vogel P., Djavadian R.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
17/07/2021
Peer-reviewed
Oui
Volume
22
Number
14
Pages
7664
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Shrews are small animals found in many different habitats. Like other mammals, adult neurogenesis occurs in the subventricular zone of the lateral ventricle (SVZ) and the dentate gyrus (DG) of the hippocampal formation. We asked whether the number of new generated cells in shrews depends on their brain size. We examined Crocidura russula and Neomys fodiens, weighing 10-22 g, and Crocidura olivieri and Suncus murinus that weigh three times more. We found that the density of proliferated cells in the SVZ was approximately at the same level in all species. These cells migrated from the SVZ through the rostral migratory stream to the olfactory bulb (OB). In this pathway, a low level of neurogenesis occurred in C. olivieri compared to three other species of shrews. In the DG, the rate of adult neurogenesis was regulated differently. Specifically, the lowest density of newly generated neurons was observed in C. russula, which had a substantial number of new neurons in the OB compared with C. olivieri. We suggest that the number of newly generated neurons in an adult shrew's brain is independent of the brain size, and molecular mechanisms of neurogenesis appeared to be different in two neurogenic structures.
Keywords
Animals, Body Weight, Brain/anatomy & histology, Brain/physiology, Cell Movement/physiology, Cell Proliferation, Hippocampus/anatomy & histology, Hippocampus/physiology, Lateral Ventricles/anatomy & histology, Lateral Ventricles/physiology, Neurogenesis, Neurons/physiology, Olfactory Bulb/anatomy & histology, Olfactory Bulb/physiology, Organ Size, Shrews/anatomy & histology, Shrews/physiology, BrdU, doublecortin, hippocampal neurogenesis, olfactory bulb, rostral migratory stream, shrews
Pubmed
Web of science
Open Access
Yes
Create date
02/08/2021 15:05
Last modification date
13/01/2024 8:08
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