The challenge of mapping the human connectome based on diffusion tractography.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_63E8848E9B7C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The challenge of mapping the human connectome based on diffusion tractography.
Journal
Nature communications
Author(s)
Maier-Hein K.H., Neher P.F., Houde J.C., Côté M.A., Garyfallidis E., Zhong J., Chamberland M., Yeh F.C., Lin Y.C., Ji Q., Reddick W.E., Glass J.O., Chen D.Q., Feng Y., Gao C., Wu Y., Ma J., Renjie H., Li Q., Westin C.F., Deslauriers-Gauthier S., González JOO, Paquette M., St-Jean S., Girard G., Rheault F., Sidhu J., Tax CMW, Guo F., Mesri H.Y., Dávid S., Froeling M., Heemskerk A.M., Leemans A., Boré A., Pinsard B., Bedetti C., Desrosiers M., Brambati S., Doyon J., Sarica A., Vasta R., Cerasa A., Quattrone A., Yeatman J., Khan A.R., Hodges W., Alexander S., Romascano D., Barakovic M., Auría A., Esteban O., Lemkaddem A., Thiran J.P., Cetingul H.E., Odry B.L., Mailhe B., Nadar M.S., Pizzagalli F., Prasad G., Villalon-Reina J.E., Galvis J., Thompson P.M., Requejo F.S., Laguna P.L., Lacerda L.M., Barrett R., Dell'Acqua F., Catani M., Petit L., Caruyer E., Daducci A., Dyrby T.B., Holland-Letz T., Hilgetag C.C., Stieltjes B., Descoteaux M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
07/11/2017
Peer-reviewed
Oui
Volume
8
Number
1
Pages
1349
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations.
Pubmed
Web of science
Open Access
Yes
Create date
27/11/2017 18:31
Last modification date
30/04/2021 7:11
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