Preliminary report: activation of the cerebellum in essential tremor.

Details

Serval ID
serval:BIB_63D33454D020
Type
Article: article from journal or magazin.
Collection
Publications
Title
Preliminary report: activation of the cerebellum in essential tremor.
Journal
Lancet
Author(s)
Colebatch J.G., Findley L.J., Frackowiak R.S., Marsden C.D., Brooks D.J.
ISSN
0140-6736 (Print)
ISSN-L
0140-6736
Publication state
Published
Issued date
1990
Volume
336
Number
8722
Pages
1028-1030
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Several images of cerebral blood flow were recorded during inhalation of carbon-15-labelled carbon dioxide by positron emission tomography in four patients with essential tremor and four normal controls. Unilateral involuntary postural tremor in essential tremor patients was associated with blood flow significantly greater than that at rest in the contralateral sensorimotor cortex, both lateral premotor regions, and both cerebellar hemispheres. Of these regions, only the cerebellum was not activated in normal controls holding a posture without tremor or in essential tremor patients undergoing passive wrist movement. The increased flow in the cerebellum therefore seems to represent neural activity involved in tremor generation. It is proposed that essential tremor is due to oscillation within cerebello-olivary pathways, relayed by way of the thalamus and motor cortex to the spinal cord.
Keywords
Administration, Inhalation, Carbon Dioxide/administration & dosage, Carbon Dioxide/diagnostic use, Carbon Radioisotopes/administration & dosage, Carbon Radioisotopes/diagnostic use, Cerebellum/physiopathology, Cerebellum/radionuclide imaging, Cerebrovascular Circulation, Color, Evaluation Studies as Topic, Humans, Middle Aged, Posture, Time Factors, Tomography, Emission-Computed/methods, Tremor/physiopathology, Tremor/radionuclide imaging, Wrist/physiopathology
Pubmed
Web of science
Create date
06/10/2011 20:02
Last modification date
20/08/2019 14:20
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