Sepsis: a roadmap for future research.

Details

Serval ID
serval:BIB_63D1529605A7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Sepsis: a roadmap for future research.
Journal
Lancet. Infectious Diseases
Author(s)
Cohen J., Vincent J.L., Adhikari N.K., Machado F.R., Angus D.C., Calandra T., Jaton K., Giulieri S., Delaloye J., Opal S., Tracey K., van der Poll T., Pelfrene E.
ISSN
1474-4457 (Electronic)
ISSN-L
1473-3099
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
15
Number
5
Pages
581-614
Language
english
Abstract
Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early recognition allowing correct therapeutic measures to be started rapidly, including administration of appropriate antibiotics, source control measures when necessary, and resuscitation with intravenous fluids and vasoactive drugs when needed. Although substantial developments have been made in the understanding of the basic pathogenesis of sepsis and the complex interplay of host, pathogen, and environment that affect the incidence and course of the disease, sepsis has stubbornly resisted all efforts to successfully develop and then deploy new and improved treatments. Existing models of clinical research seem increasingly unlikely to produce new therapies that will result in a step change in clinical outcomes. In this Commission, we set out our understanding of the clinical epidemiology and management of sepsis and then ask how the present approaches might be challenged to develop a new roadmap for future research.
Pubmed
Web of science
Create date
22/05/2015 16:42
Last modification date
20/08/2019 14:20
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