Diagnostic performance of urinary metanephrines for the postmortem diagnosis of hypothermia.

Details

Serval ID
serval:BIB_63BD391AE89C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diagnostic performance of urinary metanephrines for the postmortem diagnosis of hypothermia.
Journal
Forensic Science, Medicine, and Pathology
Author(s)
Palmiere C., Teresiński G., Hejna P., Mangin P., Grouzmann E.
ISSN
1556-2891 (Electronic)
ISSN-L
1547-769X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
10
Number
4
Pages
518-525
Language
english
Notes
Publication types: Publication Status: ppublish
Abstract
The purpose of this study was to assess the diagnostic potential of urinary metanephrines and 3-methoxytyramine compared to urinary catecholamine determination in diagnosing antemortem cold exposure and fatal hypothermia. 83 cases of fatal hypothermia and 144 control cases were included in this study. Catecholamines (adrenaline, noradrenaline and dopamine), metanephrines (metanephrine, normetanephrine) and 3-methoxytyramine were measured in urine collected during autopsy. All tested analytes were significantly higher in hypothermia cases compared to control subjects and displayed a generally satisfying discriminative value, thus indicating urinary catecholamines and their metabolites as reliable markers of cold-related stress and hypothermia related-deaths. Metanephrine and adrenaline had the best discriminative value between hypothermia and control cases compared to other tested analytes, though with different sensitivity and specificity. These can therefore be considered the most suitable markers of cold-related stress.
Pubmed
Web of science
Create date
18/12/2014 19:33
Last modification date
20/08/2019 15:20
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