Impact of stroke volume on motor outcome in neonatal arterial ischemic stroke.

Details

Serval ID
serval:BIB_638C26D1A5BE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of stroke volume on motor outcome in neonatal arterial ischemic stroke.
Journal
European journal of paediatric neurology
Author(s)
Wiedemann A., Pastore-Wapp M., Slavova N., Steiner L., Weisstanner C., Regényi M., Steinlin M., Grunt S.
Working group(s)
Swiss Neuropediatric Stroke Registry Group
Contributor(s)
Mori A.C., Bigi S., Datta A., Fluss J., Hackenberg A., Keller E., MacKay M.T., Maier O., Mercati D., Marcoz J.P., Poloni C., Ramelli G.P., Regényi M., Schmid R., Schmitt-Mechelke T.
ISSN
1532-2130 (Electronic)
ISSN-L
1090-3798
Publication state
Published
Issued date
03/2020
Peer-reviewed
Oui
Volume
25
Pages
97-105
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Neonatal arterial ischemic stroke (NAIS) can lead to long-term neurological consequences such as cerebral palsy (CP). The aim of this study was to evaluate the predictive value of acute diffusion-weighted imaging (DWI) for CP by analyzing stroke volume next to brain structure involvement.
We included 37 term-born infants with NAIS prospectively registered in a nationwide pediatric stroke registry. DWI was performed between 0 and 8 days (mean 3 days) after stroke manifestation. Participants were neurologically assessed at the age of 2 years. We calculated the stroke volume (in mm <sup>3</sup> ) and the ratio of the stroke volume to the volume of the entire brain (relative stroke volume). The predictive value of the relative stroke volume was analyzed and an optimal threshold for classification of children with high- and low-rates of CP was calculated. Predictive value of brain structure involvements and the prevalence of CP in combinations of different brain structures was also assessed.
Sixteen children (43.2%) developed CP. Relative stroke volume significantly predicted CP (p < .001). Its optimal threshold for division into high- and low-rate of CP was 3.3%. The basal ganglia (OR 8.3, 95% CI 1.2-60.0) and basis pontis (OR 18.5, 95% CI 1.8-194.8) were independently associated with CP.
In addition to determining the involvement of affected brain areas, the volumetric quantification of stroke volume allows accurate prediction of cerebral palsy in newborns with NAIS.
Keywords
Brain/diagnostic imaging, Brain/pathology, Brain Ischemia/complications, Brain Ischemia/diagnostic imaging, Brain Ischemia/pathology, Cerebral Palsy/etiology, Cerebral Palsy/pathology, Child, Preschool, Diffusion Magnetic Resonance Imaging, Female, Humans, Infant, Newborn, Male, Stroke/complications, Stroke/diagnostic imaging, Stroke/pathology, Cerebral palsy (CP), Diffusion-weighted imaging (DWI), Neonatal arterial ischemic stroke (NAIS), Prognosis, Stroke involvement, Stroke volume
Pubmed
Web of science
Create date
10/09/2020 11:29
Last modification date
09/03/2024 7:09
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