Helicobacter-pylori-Infektion und Ulcuskrankheit [Helicobacter pylori infection and ulcer].

Details

Serval ID
serval:BIB_6385
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Helicobacter-pylori-Infektion und Ulcuskrankheit [Helicobacter pylori infection and ulcer].
Journal
der Chirurg; Zeitschrift für alle Gebiete der Operativen Medizen
Author(s)
Malfertheiner P., Blum A.L.
ISSN
0009-4722 (Print)
ISSN-L
0009-4722
Publication state
Published
Issued date
1998
Volume
69
Number
3
Pages
239-248
Language
german
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Abstract
Our understanding of ulcer pathogenesis has dramatically changed since the discovery of Heliobacter pylori. Peptic ulcer is now recognized as a chronic gastric infectious disease. H. pylori can be considered the pacemaker, with other known risk factors ultimately contributing to the ulcer formation. Treatment of H. pylori in peptic ulcer disease cures the acute lesion and prevents relapse and complications. In clinical management a positive diagnosis of H. pylori is required and other potential causes for ulcer formation must be excluded before starting treatment. The standard treatment in H. pylori positive ulcer consists of PPI in standard dose and two antibiotics either clarithromycin 2 x 500 mg and amoxycillin 2 x 1 g or metronidazole 2 x 400 mg and clarithromycin 2 x 250 mg (or 500 mg) for 7 days. The simultaneous presence of H. pylori and NSAID intake requires distinct management. Following bleeding complication a PPI needs to be given beyond 7 days until ulcer healing is endoscopically confirmed.
Keywords
Amoxicillin/administration & dosage, Clarithromycin/administration & dosage, Drug Therapy, Combination/therapeutic use, Helicobacter Infections/complications, Helicobacter Infections/drug therapy, Helicobacter pylori/drug effects, Helicobacter pylori/pathogenicity, Humans, Metronidazole/administration & dosage, Peptic Ulcer/complications, Peptic Ulcer/drug therapy, Treatment Outcome, Virulence
Pubmed
Web of science
Create date
19/11/2007 12:43
Last modification date
20/08/2019 14:20
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