Noun and verb retrieval by normal subjects. Studies with PET.

Details

Serval ID
serval:BIB_638281783E54
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Noun and verb retrieval by normal subjects. Studies with PET.
Journal
Brain
Author(s)
Warburton E., Wise R.J., Price C.J., Weiller C., Hadar U., Ramsay S., Frackowiak R.S.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Publication state
Published
Issued date
1996
Volume
119 ( Pt 1)
Pages
159-179
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
PET activation studies identify significant local changes in regional cerebral blood flow (rCBF) in contrasts of behavioural tasks with control states, and these local changes identify net changes in local synaptic activity. A number of studies on word retrieval have all demonstrated left frontal (dorsolateral and medial) involvement in the task. However, there have been differences in the responses observed in the left temporal lobe, with variously a deactivation (significant decrease in rCBF), no response and an activation (significant increase in rCBF). In the four studies described here, we have examined word (verbs and nouns) retrieval contrasted with a number of different control states. The studies confirmed extensive activation of the left dorsolateral prefrontal cortex and, medially, the anterior cingulate cortex and the supplementary motor area (SMA). Activations of the left posterior temporal lobe and the inferior parietal lobe were consistently demonstrated when word retrieval was contrasted with a rest state. Contrasts with other single word tasks controlled out the activation in the perisylvian part of the left posterior temporal lobe, suggesting a role for this region in lexical processing. The left inferolateral temporal cortex and the posterior part of the inferior parietal lobe were only activated by word retrieval, particularly verbs. It is proposed that these activated regions reflect access to semantic fields.
Keywords
Adult, Aged, Brain/blood supply, Brain/physiology, Cerebrovascular Circulation, Female, Humans, Language, Male, Memory/physiology, Middle Aged, Reference Values, Regional Blood Flow, Speech Perception/physiology, Tomography, Emission-Computed
Pubmed
Web of science
Open Access
Yes
Create date
16/09/2011 19:12
Last modification date
20/08/2019 14:20
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