Localized fibrous tumours of the pleura: 15 new cases and review of the literature.

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_6325208B6327
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Localized fibrous tumours of the pleura: 15 new cases and review of the literature.
Journal
European Journal of Cardio-thoracic Surgery
Author(s)
Suter M., Gebhard S., Boumghar M., Peloponisios N., Genton C.Y.
ISSN
1010-7940 (Print)
ISSN-L
1010-7940
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
14
Number
5
Pages
453-459
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
licence nationale
Abstract
OBJECTIVE: To present a series of localized fibrous tumours of the pleura (LFTP), to define the clinical and histopathological diagnostic criteria of this tumour, and to determine the optimal treatment and follow-up.
METHODS: Review of the charts of the patients with the diagnosis of LFTP (formerly called benign fibrous mesothelioma), as well as of all the histological sections, including immunohistochemical stains. Review of the literature with special emphasis on the clinical and histological criteria of malignancy.
RESULTS: During the last 30 years, we found 15 patients with a complete clinical chart and histological material, particularly paraffin blocks of the tumour. The mean age was 57 years (range 27-79). Eight patients were asymptomatic, and the remaining seven presented with non-specific symptoms. All but one had complete resection of the tumour, including partial lung resection in two and partial chest wall resection in three. The diagnosis was confirmed by histological review in 15 cases. Immunohistochemical stainings showed positivity for vimentin in all cases, for CD 34 in 80%, but were consistently negative for cytokeratins. Nine tumours were histologically classified as malignant. Among them, five recurred, two of which were responsible for death. One benign tumour recurred after 1 year, and was treated successfully by repeat resection and radiotherapy. Overall, 13 patients (86%) were alive with no evidence of disease between 10 months and 27 years after the first resection.
CONCLUSIONS: LFTP is a rare tumour which has a benign clinical course in over 80% of the cases, and is asymptomatic in half the patients. The diagnosis is difficult to establish before operation. Treatment consists of complete resection including adjacent structures if necessary. The clinical behaviour of LFTP cannot be predicted on the basis of histological aspects only. If histologically malignant tumours are more prone to recurrence and poor outcome, broad-based and locally invasive tumours bear a higher risk of recurrence. Long term follow-up is therefore mandatory in all cases in order to perform early re-resection when recurrence occurs.
Keywords
Female, Humans, Immunohistochemistry, Male, Mesothelioma/diagnosis, Mesothelioma/epidemiology, Middle Aged, Neoplasm Recurrence, Local/epidemiology, Pleura/metabolism, Pleura/pathology, Pleural Neoplasms/diagnosis, Pleural Neoplasms/epidemiology, Survival Rate, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 18:34
Last modification date
25/09/2019 6:09
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