A critical role for system A amino acid transport in the regulation of dendritic development by brain-derived neurotrophic factor (BDNF).

Details

Serval ID
serval:BIB_630BD891ADA7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A critical role for system A amino acid transport in the regulation of dendritic development by brain-derived neurotrophic factor (BDNF).
Journal
Journal of Biological Chemistry
Author(s)
Burkhalter J., Fiumelli H., Erickson J.D., Martin J.L.
ISSN
0021-9258
Publication state
Published
Issued date
02/2007
Peer-reviewed
Oui
Volume
282
Number
8
Pages
5152-5159
Language
english
Notes
Publication types: Journal Article
Abstract
Dendritic development is essential for the establishment of a functional nervous system. Among factors that control dendritic development, brain-derived neurotrophic factor (BDNF) has been shown to regulate dendritic length and complexity of cortical neurons. However, the cellular and molecular mechanisms that underlie these effects remain poorly understood. In this study, we examined the role of amino acid transport in mediating the effects of BDNF on dendritic development. We show that BDNF increases System A amino acid transport in cortical neurons by selective up-regulation of the sodium-coupled neutral amino acid transporter (SNAT)1. Up-regulation of SNAT1 expression and System A activity is required for the effects of BDNF on dendritic growth and branching of cortical neurons. Further analysis revealed that induction of SNAT1 expression and System A activity by BDNF is necessary in particular to enhance synthesis of tissue-type plasminogen activator, a protein that we demonstrate to be essential for the effects of BDNF on cortical dendritic morphology. Together, these data reveal that stimulation of neuronal differentiation by BDNF requires the up-regulation of SNAT1 expression and System A amino acid transport to meet the increased metabolic demand associated with the enhancement of dendritic growth and branching.
Keywords
Amino Acid Transport System A/biosynthesis, Animals, Brain-Derived Neurotrophic Factor/pharmacology, Cell Differentiation/drug effects, Cell Differentiation/physiology, Cell Enlargement/drug effects, Cells, Cultured, Cerebral Cortex/cytology, Cerebral Cortex/physiology, Dendrites/physiology, Mice, Up-Regulation/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
30/01/2008 11:21
Last modification date
20/08/2019 14:19
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