The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter

Details

Serval ID
serval:BIB_62D141735E64
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter
Journal
Genomics
Author(s)
Kozlov  S. V., Giger  R. J., Hasler  T., Korvatska  E., Schorderet  D. F., Sonderegger  P.
ISSN
0888-7543 (Print)
Publication state
Published
Issued date
11/1995
Volume
30
Number
2
Pages
141-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 20
Abstract
The human TAX-1 gene (HGMW-approved symbol TAX1) is located on chromosome 1 (1q32.1) and encodes the neuronal cell adhesion molecule TAG-1/axonin-1. The gene product, termed TAG-1 in the rat and axonin-1 in the chicken, is composed of six immunoglobulin (Ig)-like and four fibronectin type III (FNIII)-like domains. It is found predominantly on the axons of particular nerve fiber tracts during neural development, and it has been demonstrated to function as a potent substratum for neurite outgrowth in vitro. Here we report the cloning and structural characterization of the TAX-1 gene. The transcribed region of the TAX-1 gene extends over about 40 kb. Like its chicken homologue, the human TAX-1 gene consists of 23 exons. Two GT/CA microsatellites were localized in the first intron; a polymorphism was found for one of them. Reporter gene analysis with serially truncated fragments of the 5'-flanking region indicated that a 164-bp fragment located immediately upstream of the putative transcription initiation site was sufficient to function as a basal promoter.
Keywords
Animals Base Sequence Cell Adhesion Molecules, Neuronal/*genetics Chickens Chromosome Mapping Cloning, Molecular Exons Genes, Reporter Humans Introns Molecular Sequence Data *Promoter Regions (Genetics) Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid
Pubmed
Web of science
Create date
28/01/2008 12:58
Last modification date
20/08/2019 14:19
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