Specific binding of antigenic peptides to cell-associated MHC class I molecules.

Details

Serval ID
serval:BIB_62CC05F6139B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Specific binding of antigenic peptides to cell-associated MHC class I molecules.
Journal
Nature
Author(s)
Luescher I.F., Romero P., Cerottini J.C., Maryanski J.L.
ISSN
0028-0836
Publication state
Published
Issued date
1991
Peer-reviewed
Oui
Volume
351
Number
6321
Pages
72-74
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
T lymphocytes recognize antigen in the form of peptides that associate with specific alleles of class I or class II major histocompatibility (MHC) molecules. By contrast with the clear MHC allele-specific binding of peptides to purified class II molecules purified solubilized class I molecules either bind relatively poorly or show degenerate specificity. Using photo-affinity labelling, we demonstrate here the specific interaction of peptides with cell-associated MHC class I molecules and show that this involves metabolically active processes.
Keywords
Affinity Labels, Amino Acid Sequence, Animals, Antibodies, Monoclonal/diagnostic use, Antigens, Protozoan/immunology, Binding, Competitive, Cell Line, Histocompatibility Antigens Class I/immunology, Kinetics, L Cells (Cell Line)/immunology, Mice, Molecular Sequence Data, Plasmodium berghei/immunology, Protein Binding, Protozoan Proteins, T-Lymphocytes/immunology
Pubmed
Web of science
Create date
28/01/2008 11:19
Last modification date
20/08/2019 14:19
Usage data