Tigecycline in combination with other antimicrobials: a review of in vitro, animal and case report studies.
Details
Serval ID
serval:BIB_62B7860A6481
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tigecycline in combination with other antimicrobials: a review of in vitro, animal and case report studies.
Journal
International Journal of Antimicrobial Agents
ISSN
1872-7913[electronic], 0924-8579[linking]
Publication state
Published
Issued date
2009
Volume
34
Number
1
Pages
8.e1-8.e9
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Tigecycline has been investigated in combination with other antibacterials against a wide range of susceptible and multiresistant Gram-positive and Gram-negative bacteria. Combinations have been analysed in vitro, in animal models and in human case reports. In vitro, tigecycline combined with other antimicrobials produces primarily an indifferent response (neither synergy nor antagonism). Nevertheless, synergy occurred when tigecycline was combined with rifampicin against 64-100% of Enterococcus spp., Streptococcus pneumoniae, Enterobacter spp. and Brucella melitensis isolates. Combinations of tigecycline with amikacin also showed synergy for 40-100% of Enterobacter spp., Klebsiella pneumoniae, Proteus spp. and Stenotrophomonas maltophilia isolates. Moreover, bactericidal synergisms occurred with tigecycline plus amikacin against problematic Acinetobacter baumannii and Proteus vulgaris, and with colistin against K. pneumoniae. Data from animal experiments and case reports, although limited, displayed consistent beneficial activity of tigecycline in combination with other antibacterials against multiresistant organisms, including vancomycin against penicillin-resistant S. pneumoniae in experimental meningitis, gentamicin against Pseudomonas aeruginosa in experimental pneumonia, daptomycin against Enterococcus faecium endocarditis, and colistin against K. pneumoniae bacteraemia and P. aeruginosa osteomyelitis. Antagonism was extremely rare in vitro and was not reported in vivo. Thus, tigecycline may be combined with a second antimicrobial as part of a combination regimen.
Keywords
Animals, Anti-Bacterial Agents/therapeutic use, Drug Synergism, Drug Therapy, Combination, Gram-Negative Bacterial Infections/drug therapy, Gram-Negative Bacterial Infections/veterinary, Gram-Positive Bacterial Infections/drug therapy, Gram-Positive Bacterial Infections/veterinary, Humans, Microbial Sensitivity Tests, Microbial Viability, Minocycline/analogs &, derivatives, Minocycline/therapeutic use
Pubmed
Web of science
Create date
14/01/2010 15:41
Last modification date
20/08/2019 14:19