Significance of serum adiponectin levels in patients with chronic liver disease.

Details

Serval ID
serval:BIB_62B5F79BE81C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Significance of serum adiponectin levels in patients with chronic liver disease.
Journal
Clinical science
Author(s)
Balmer M.L., Joneli J., Schoepfer A., Stickel F., Thormann W., Dufour J.F.
ISSN
1470-8736 (Electronic)
ISSN-L
0143-5221
Publication state
Published
Issued date
05/08/2010
Peer-reviewed
Oui
Volume
119
Number
10
Pages
431-436
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Adiponectin, which plays a pivotal role in metabolic liver diseases, is reduced in concentration in patients with NASH (non-alcoholic steatohepatitis). The aim of the present study was to determine adiponectin concentrations in patients with different forms and stages of chronic liver diseases. Serum adiponectin concentrations were measured in 232 fasting patients with chronic liver disease: 64 with NAFLD (non-alcoholic fatty liver disease), 123 with other chronic liver disease (e.g. viral hepatitis, n=71; autoimmune disease, n=18; alcohol-induced liver disease, n=3; or elevated liver enzymes of unknown origin, n=31) and 45 with cirrhosis. Circulating adiponectin levels were significantly lower in patients with NAFLD in comparison with patients with other chronic liver disease (4.8+/-3.5 compared with 10.4+/-6.3 microg/ml respectively; P<0.0001). Circulating adiponectin levels were significantly higher in patients with cirrhosis in comparison with patients without cirrhosis (18.6+/-14.5 compared with 8.4+/-6.1 microg/ml respectively; P<0.0001). Adiponectin concentrations correlated negatively with body weight (P<0.001), serum triacylglycerols (triglycerides) (P<0.001) and, in women, with BMI (body mass index) (P<0.001). Adiponectin concentrations correlated positively with serum bile acids (P<0.001), serum hyaluronic acid (P<0.001) and elastography values (P<0.001). Adiponectin levels were decreased in patients with NAFLD. In conclusion, adiponectin levels correlate positively with surrogate markers of hepatic fibrosis (transient elastography, fasting serum bile acids and hyaluronate) and are significantly elevated in cases of cirrhosis.
Keywords
Adiponectin/blood, Adult, Anthropometry, Bile Acids and Salts/blood, Biomarkers/blood, Body Mass Index, Chronic Disease, Diagnosis, Differential, Elasticity Imaging Techniques, Fatty Liver/blood, Fatty Liver/diagnosis, Female, Humans, Hyaluronic Acid/blood, Liver Cirrhosis/blood, Liver Cirrhosis/diagnosis, Liver Diseases/blood, Liver Diseases/diagnosis, Male, Middle Aged, Prospective Studies, Sex Factors
Pubmed
Web of science
Open Access
Yes
Create date
01/02/2011 15:53
Last modification date
01/07/2024 18:23
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