Consequences of gestational diabetes mellitus on neonatal cardiovascular health: MySweetHeart Cohort study.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_629CA1A1FA20
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Consequences of gestational diabetes mellitus on neonatal cardiovascular health: MySweetHeart Cohort study.
Journal
Pediatric research
Author(s)
Di Bernardo S., Lava SAG, Epure A.M., Younes S.E., Chiolero A., Sekarski N.
Working group(s)
MySweetHeart Research Group
Contributor(s)
Arhab A., Bovet P., Chiolero A., Di Bernardo S., Epure A.M., Gilbert L., Gross J., Horsch A., Lanzi S., Mayerat S., Mivelaz Y., Puder J.J., Quansah D., Rossel J.B., Simeoni U., Stuijfzand B., Vial Y.
ISSN
1530-0447 (Electronic)
ISSN-L
0031-3998
Publication state
Published
Issued date
07/2023
Peer-reviewed
Oui
Volume
94
Number
1
Pages
231-238
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Hyperglycaemic disorders of pregnancy are associated with offspring cardiovascular alterations.
MySweetHeart cohort study aimed to assess the effect of maternal gestational diabetes (GDM) on offsprings' cardiovascular health. Newborns underwent clinical and echocardiographic examinations between 2016 and 2020.
Compared to mothers without GDM (n = 141), mothers with GDM (n = 123) were more likely to have had GDM in previous pregnancies and had higher weight, BMI, blood glucose, and HbA1c. Newborns of both groups showed similar clinical characteristics. Echocardiography was performed on the 3rd (interquartile range, IQR, 2nd-4th) day of life in 101 offsprings of mothers without and 116 offsprings of mothers with GDM. Left ventricular (LV) mass was similar. Children born to mothers with GDM had a thicker posterior LV wall (z-score +0.15, IQR -0.38/0.62, versus +0.47, IQR -0.11/+1.1, p = 0.004), a smaller end-systolic (1.3 mL, IQR 1.0-1.5 mL, versus 1.4 mL, IQR 1.2-1.8 mL, p = 0.044) but a similar end-diastolic LV volume. They also had shorter tricuspid valve flow duration and aortic valve ejection time, lower tricuspid E-wave and pulmonary valve velocities.
Newborns of mothers with or without GDM had similar clinical characteristics and LV mass. However, some echocardiographic differences were detected, suggesting an altered myocardial physiology among infants of mothers with GDM.
ClinicalTrials.gov (NCT02872974).
Hyperglycaemic disorders of pregnancy are known to be associated with offspring cardiovascular alterations. Clinical characteristics and estimated left ventricular (LV) mass were similar in children issued from mothers with and without gestational diabetes (GDM). Children born to mothers with GDM had a thicker posterior LV wall and a smaller end-systolic LV volume. Although LV mass is not different, myocardial physiology may be altered in these infants. Further studies should investigate the endothelial function of this population and the cardiovascular evolution of these children over time.
Keywords
Pregnancy, Infant, Child, Female, Humans, Infant, Newborn, Diabetes, Gestational, Cohort Studies, Mothers, Overweight/epidemiology, Hyperglycemia
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 32003B-163240
Create date
01/12/2022 19:17
Last modification date
07/08/2024 7:06
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