A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine.

Details

Serval ID
serval:BIB_628813545B4D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine.
Journal
Forensic Science International
Author(s)
Kintz P., Tracqui A., Mangin P., Lugnier A.A., Chaumont A.J.
ISSN
0379-0738[print], 0379-0738[linking]
Publication state
Published
Issued date
1989
Volume
40
Number
2
Pages
153-159
Language
english
Abstract
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard. No derivation is necessary and after a single alkaline extraction, GC analysis for the 11 compounds tested is achieved in 23 min. The lower limit of detectability was found to be 4 ng/ml for amphetamine in plasma. This method is sensitive, reproducible, selective and applicable in forensic and clinical toxicological analyses. Toxicological findings, after a fatality involving phendimetrazine are presented as an application of the procedure.
Keywords
Adult, Amphetamine/analysis, Central Nervous System Stimulants/analysis, Chromatography, Gas, Doping in Sports, Humans, Male, Morpholines/analysis, Morpholines/poisoning
Pubmed
Create date
15/10/2010 13:57
Last modification date
20/08/2019 15:19
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