Endurance Training with or without Glucose-Fructose Ingestion: Effects on Lactate Metabolism Assessed in a Randomized Clinical Trial on Sedentary Men.

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State: Public
Version: Final published version
Serval ID
serval:BIB_626F858B7CD2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Endurance Training with or without Glucose-Fructose Ingestion: Effects on Lactate Metabolism Assessed in a Randomized Clinical Trial on Sedentary Men.
Journal
Nutrients
Author(s)
Rosset R., Lecoultre V., Egli L., Cros J., Rey V., Stefanoni N., Sauvinet V., Laville M., Schneiter P., Tappy L.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Publication state
Published
Issued date
20/04/2017
Peer-reviewed
Oui
Volume
9
Number
4
Pages
0
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: epublish
Abstract
Glucose-fructose ingestion increases glucose and lactate oxidation during exercise. We hypothesized that training with glucose-fructose would induce key adaptations in lactate metabolism. Two groups of eight sedentary males were endurance-trained for three weeks while ingesting either glucose-fructose (GF) or water (C). Effects of glucose-fructose on lactate appearance, oxidation, and clearance were measured at rest and during exercise, pre-training, and post-training. Pre-training, resting lactate appearance was 3.6 ± 0.5 vs. 3.6 ± 0.4 mg·kg javax.xml.bind.JAXBElement@1ca983d4 ·min javax.xml.bind.JAXBElement@7b9c8542 in GF and C, and was increased to 11.2 ± 1.4 vs. 8.8 ± 0.7 mg·kg javax.xml.bind.JAXBElement@1db23ebc ·min javax.xml.bind.JAXBElement@7d82d9ab by exercise (Exercise: javax.xml.bind.JAXBElement@2d6552ec < 0.01). Lactate oxidation represented 20.6% ± 1.0% and 17.5% ± 1.7% of lactate appearance at rest, and 86.3% ± 3.8% and 86.8% ± 6.6% during exercise (Exercise: javax.xml.bind.JAXBElement@324c6497 < 0.01) in GF and C, respectively. Training with GF increased resting lactate appearance and oxidation (Training × Intervention: both javax.xml.bind.JAXBElement@3e07fbbc < 0.05), but not during exercise (Training × Intervention: both javax.xml.bind.JAXBElement@55a33256 > 0.05). Training with GF and C had similar effects to increase lactate clearance during exercise (+15.5 ± 9.2 and +10.1 ± 5.9 mL·kg javax.xml.bind.JAXBElement@52d6e83c ·min javax.xml.bind.JAXBElement@3ef562d ; Training: javax.xml.bind.JAXBElement@23497f7 < 0.01; Training × Intervention: javax.xml.bind.JAXBElement@4ec92465 = 0.97). The findings of this study show that in sedentary participants, glucose-fructose ingestion leads to high systemic lactate appearance, most of which is disposed non-oxidatively at rest and is oxidized during exercise. Training with or without glucose-fructose increases lactate clearance, without altering lactate appearance and oxidation during exercise.

Keywords
Adult, Blood Glucose/metabolism, Body Mass Index, Exercise, Fructose/administration & dosage, Fructose/blood, Glucose/administration & dosage, Glucose/metabolism, Humans, Lactic Acid/blood, Male, Oxygen Consumption, Physical Endurance, Sedentary Lifestyle, Young Adult, carbohydrate, exercise, fructose, glucose, lactate, lactate metabolism, substrate oxidation
Pubmed
Web of science
Open Access
Yes
Create date
29/04/2017 17:19
Last modification date
20/08/2019 15:19
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