Potential Role of PSMA-Targeted PET in Thyroid Malignant Disease: A Systematic Review.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_622AE6FD8598
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Potential Role of PSMA-Targeted PET in Thyroid Malignant Disease: A Systematic Review.
Journal
Diagnostics
Author(s)
Rizzo A., Racca M., Dall'Armellina S., Delgado Bolton R.C., Albano D., Dondi F., Bertagna F., Annunziata S., Treglia G.
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Publication state
Published
Issued date
03/02/2023
Peer-reviewed
Oui
Volume
13
Number
3
Pages
564
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Recently, several studies introduced the potential use of positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals in radioiodine-refractory thyroid cancer (TC).
The authors accomplished a comprehensive literature search of original articles concerning the performance of PSMA-targeted PET/CT in TC patients. Original papers exploring this molecular imaging examination in radioiodine-refractory TC patients undergoing restaging of their disease were included.
A total of 6 documents concerning the diagnostic performance of PSMA-targeted PET/CT in TC (49 patients) were included in this systematic review. The included articles reported heterogeneous values of PSMA-targeted PET/CT detection rates in TC, ranging from 25% to 100% and overall inferior to [ <sup>18</sup> F]-fluorodeoxyglucose PET/CT when the two molecular imaging examinations were compared. Two studies reported the administration of [ <sup>177</sup> Lu]PSMA-radioligands with theragnostic purpose in three patients.
The available literature data in this setting are limited and heterogeneous. The employment of PET with PSMA-targeting radiopharmaceuticals in this setting did not affect patient management. Nevertheless, prospective multicentric studies are needed to properly assess its potential role in TC patients.
Keywords
PET, PSMA, imaging, nuclear medicine, systematic review, thyroid, thyroid cancer
Pubmed
Web of science
Open Access
Yes
Create date
07/03/2023 9:54
Last modification date
14/06/2023 7:11
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