Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis.

Details

Serval ID
serval:BIB_6227A92C8D06
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis.
Journal
Cell reports
Author(s)
Duc D., Vigne S., Bernier-Latmani J., Yersin Y., Ruiz F., Gaïa N., Leo S., Lazarevic V., Schrenzel J., Petrova T.V., Pot C.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
08/10/2019
Peer-reviewed
Oui
Volume
29
Number
2
Pages
378-390.e4
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Multiple sclerosis (MS) is a common autoimmune disease of the CNS. Although an association between MS and inflammatory bowel diseases is observed, the link connecting intestinal immune responses and neuroinflammation remains unclear. Here we show that encephalitogenic Th17 cells infiltrate the colonic lamina propria before neurological symptom development in two murine MS models, active and adoptive transfer experimental autoimmune encephalomyelitis (EAE). Specifically targeting Th17 cell intestinal homing by blocking the α4β7-integrin and its ligand MAdCAM-1 pathway impairs T cell migration to the large intestine and dampens EAE severity in the Th17 cell adoptive transfer model. Mechanistically, myelin-specific Th17 cells proliferate in the colon and affect gut microbiota composition. The beneficial effect of blocking the α4β7-integrin and its ligand MAdCAM-1 pathway on EAE is interdependent with gut microbiota. Those results show that disrupting myelin-specific Th17 cell trafficking to the large intestine harnesses neuroinflammation and suggests that the gut environment and microbiota catalyze the encephalitogenic properties of Th17 cells.
Keywords
EAE, MAdCAM-1, Th17 cells, gut-brain axis, integrin, intestinal microbiome, multiple sclerosis, neuroinflammation, trafficking, α4β7
Pubmed
Web of science
Open Access
Yes
Create date
10/10/2019 20:43
Last modification date
19/01/2021 6:24
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