Astrocyte-neuron metabolic relationships: for better and for worse.

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State: Public
Version: author
Serval ID
serval:BIB_62211B046E29
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Astrocyte-neuron metabolic relationships: for better and for worse.
Journal
Trends In Neurosciences
Author(s)
Allaman I., Bélanger M., Magistretti P.J.
ISSN
1878-108X[electronic], 0166-2236[linking]
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
34
Number
2
Pages
76-87
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
In recent years, previously unsuspected roles of astrocytes have been revealed, largely owing to the development of new tools enabling their selective study in situ. These exciting findings add to the large body of evidence demonstrating that astrocytes play a central role in brain homeostasis, in particular via the numerous cooperative metabolic processes they establish with neurons, such as the supply of energy metabolites and neurotransmitter recycling functions. Furthermore, impairments in astrocytic function are increasingly being recognized as an important contributor to neuronal dysfunction and, in particular, neurodegenerative processes. In this review, we discuss recent evidence supporting important roles for astrocytes in neuropathological conditions such as neuroinflammation, amyotrophic lateral sclerosis and Alzheimer's disease. We also explore the potential for neuroprotective therapeutics based on the modulation of astrocytic functions.
Pubmed
Web of science
Create date
11/03/2011 15:30
Last modification date
20/08/2019 14:19
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