Comparative Genomics of Clostridioides difficile.

Details

Serval ID
serval:BIB_62208635DEAF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparative Genomics of Clostridioides difficile.
Journal
Advances in experimental medicine and biology
Author(s)
Janezic S., Garneau J.R., Monot M.
ISSN
0065-2598 (Print)
ISSN-L
0065-2598
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Volume
1435
Pages
199-218
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Clostridioides difficile, a Gram-positive spore-forming anaerobic bacterium, has rapidly emerged as the leading cause of nosocomial diarrhoea in hospitals. The availability of large numbers of genome sequences, mainly due to the use of next-generation sequencing methods, has undoubtedly shown their immense advantages in the determination of C. difficile population structure. The implementation of fine-scale comparative genomic approaches has paved the way for global transmission and recurrence studies, as well as more targeted studies, such as the PaLoc or CRISPR/Cas systems. In this chapter, we provide an overview of recent and significant findings on C. difficile using comparative genomic studies with implications for epidemiology, infection control and understanding of the evolution of C. difficile.
Keywords
Clostridioides, Clostridioides difficile/genetics, Base Composition, Phylogeny, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Genomics, CRISPR/Cas, Epidemiology, Evolution, Non-toxigenic strains, Recurrence, Transmission
Pubmed
Create date
10/01/2024 14:32
Last modification date
11/01/2024 8:16
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