Successful prophylaxis of experimental streptococcal endocarditis with single doses of sublethal concentrations of penicillin.

Details

Ressource 1Download: serval:BIB_61F1B6C0ABC7.P001 (314.05 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_61F1B6C0ABC7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Successful prophylaxis of experimental streptococcal endocarditis with single doses of sublethal concentrations of penicillin.
Journal
The Journal of antimicrobial chemotherapy
Author(s)
Francioli P., Glauser M.P.
ISSN
0305-7453 (Print)
ISSN-L
0305-7453
Publication state
Published
Issued date
01/1985
Peer-reviewed
Oui
Volume
15 Suppl A
Pages
297-302
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Penicillin prophylaxis against experimental endocarditis due to a strain of Streptococcus intermedius isolated from a patient with endocarditis was studied in rats. The minimum bactericidal concentration of penicillin for this strain was more than 64 mg/l and was higher than the peak penicillin serum level obtained in rats 30 min after the iv injection of 60 mg/kg, and in man after an oral dose of 2 g of phenoxymethyl penicillin. Moreover timed kill curves performed in the presence of 64 mg/l of penicillin showed no decrease in the number of colony-forming units during the first 6 h of incubation and only a 95% decrease after 24 h. In addition, no bactericidal activity could be detected in the serum 30 min after penicillin injection, that is at the time of bacterial challenge. Using the minimum bacterial inoculum needed to produce endocarditis in 90% of control animals (ID90), penicillin successfully prevented endocarditis due to this strain. We conclude that penicillin may prevent streptococcal endocarditis by other mechanisms than bacterial killing.
Keywords
Animals, Blood Bactericidal Activity, Endocarditis, Bacterial/prevention & control, Penicillins/administration & dosage, Penicillins/blood, Penicillins/therapeutic use, Rats, Streptococcal Infections/prevention & control, Streptococcus/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 17:07
Last modification date
01/10/2019 6:18
Usage data