Evidence of directional and stabilizing selection in contemporary humans.

Details

Serval ID
serval:BIB_61C8FCD48B99
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evidence of directional and stabilizing selection in contemporary humans.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Sanjak J.S., Sidorenko J., Robinson M.R., Thornton K.R., Visscher P.M.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
02/01/2018
Peer-reviewed
Oui
Volume
115
Number
1
Pages
151-156
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Abstract
Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features of contemporary human evolution. Here we leverage the UK Biobank data to test for the presence of linear and nonlinear natural selection in a contemporary population of the United Kingdom. We obtain phenotypic and genetic evidence consistent with the action of linear/directional selection. Phenotypic evidence suggests that stabilizing selection, which acts to reduce variance in the population without necessarily modifying the population mean, is widespread and relatively weak in comparison with estimates from other species.
Keywords
Biological Evolution, Female, Humans, Male, Middle Aged, Models, Genetic, Phenotype, Selection, Genetic, United Kingdom, complex traits, natural selection, stabilizing selection
Pubmed
Web of science
Open Access
Yes
Create date
10/01/2018 9:24
Last modification date
20/08/2019 14:18
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