Retreatment of recurrent head and neck cancer in a previously irradiated field.

Details

Serval ID
serval:BIB_61BE68C8B3AF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Retreatment of recurrent head and neck cancer in a previously irradiated field.
Journal
Seminars in Radiation Oncology
Author(s)
Wong S.J., Bourhis J., Langer C.J.
ISSN
1532-9461 (Electronic)
ISSN-L
1053-4296
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
22
Number
3
Pages
214-219
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
During the past 2 decades, concurrent chemotherapy with reirradiation (reRT) has matured from a fear-provoking, rarely performed therapeutic strategy to an accepted mainstream option for selected patients with recurrent or second primary squamous cell head and neck cancer in previously irradiated fields. Attempts by investigators to advance and improve reRT have included multiple new approaches, such as the use of reRT in the postoperative setting, the integration of new radiation techniques, as well as the addition of targeted agents into reRT regimens. We review and discuss recent studies that address these areas. Although clinical research efforts to examine new reRT regimens are valuable, we have reached a plateau in the acquisition of significant new knowledge because of a paucity of prospective multicenter studies and a near total absence of randomized phase III trials. Analysis of recent reRT studies points out areas where incremental advances have been made, but more importantly, we provide a guide to the priorities on which future investigations should focus.
Keywords
Chemoradiotherapy, Combined Modality Therapy, Head and Neck Neoplasms/radiotherapy, Humans, Induction Chemotherapy, Molecular Targeted Therapy, Neoplasm Recurrence, Local/therapy, Neoplasms, Second Primary/therapy, Neoplasms, Squamous Cell/radiotherapy, Neoplasms, Squamous Cell/secondary, Radiation Injuries, Radiosurgery, Radiotherapy Dosage, Retreatment
Pubmed
Web of science
Create date
15/02/2013 16:24
Last modification date
20/08/2019 14:18
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